Agricultural cleaner production is the key to food safety and a novel creative way of thinking in modern agricultural production. It refers to end-to-end control and waste minimization of agricultural production and production of qualified wholesome food, which is oriented toward materializing the target of environment health and food safety for the mankind. In January 2002, Jiangsu launched a experiment and demonstration project on agricultural cleaner production technical and management system. The project lasted over two years and achieved some results and accumulated some valuable experience in agricultural cleaner production that worth referencing. This paper is trying to summarize comprehensively experience of the project for related parties to use as reference.