The spatial variability and its dominating factors of soil available lead (Pb), zinc (Zn), copper (Cu) and cadmium (Cd) in a small-scaled region in the suburbs of Nanjing City was studied through the method of geostatistics coupled with Geographic Information System (GIS). The results showed:(1)in terms of spatial variation soil available Zn was higher, soil available Pb relatively lower and soil available Cu and Cd medium; (2)soil available Pb and Zn were auto-correlated to a moderate degree while the soil available Cu and Cd were done to a high degree. The spatial scale of auto-correlation of Zn and Cd was relatively large, 2088m and 1077m, respectively, while that of Cu and Pb was relatively small, 375m and 800m, respectively. The dominating factors of the accumulation of Pb, Zn, Cu and Cd included traffic, irrigation with sewage, application of cow manure, landform, etc.