Exposure of veterinary medicines to the environment has aroused great concern over the last decade, but only a little has been reported on their adverse effects on aquatic environment, and even less on terrestrial environment. Therefore, very little is known about the exposure routes of veterinary medicines into and their behaviors in soils. Several substances, such as oxytetracycline, which are persistent in soils, may be potential threat to the environment. This paper reviews present researches on pathways, fate and effects of veterinary medicines on terrestrial environment.