Yangtse and Pearl River Delta regions are the most developed regions of China, while their environmental pollution problems are rather serious. People have been trying to solve the problem with different kind of methods, but the effects are not in line with the expectation. This article is to introduce the DPSIR (Drive Force-Presure-State-Impact-Response) framework to these areas to cope with the environmental deterioration. Moreover, this article also conceives of the combination of game theory and DPSIR framework to tackle the environmental problems.