Being an important component of the soil ecosystem and an active participator of material cycling, soil enzymes play a key role in underground ecological process in the terrestrial ecosystem. Elevation of temperature and/or atmospheric CO₂ concentration may impact the activity of soil enzymes directly or indirectly. However, studies on influences of enhanced temperature and/or CO₂ concentrations on feedback mechanism and process of soil enzymes are inadequate. Advancements and progresses of the studies on soil enzymes in relation to temperature and CO₂ are reviewed, and recommendations presented for further systematic researches on relations between soil enzymes and factors of global changes.