Effects of soil microorganism, temperature, soil moisture and pH on degradation of famoxadone were studied. Data showed that DT₅₀ of famoxadone in sterilized soil was 27.6 times slower than in non-sterilized soil, indicating microorganism was a dominant factor affecting degradation of famoxadone in soil. Some environment factors including temperature, soil moisture, etc. could also affect degradation of famoxadone in soil. The degradation was accelerated significantly when the temperature increased from 15℃ to 40℃, especially from 15℃ to 25℃. It was optimal for famoxadone to degrade, when soil moisture was in the range of 50% FC-100% FC. But soil pH did not have much influence on the degradation.