Pot experiments were conducted to study the effects of Pb, Cd and As in single and combined forms in three different kinds of soils on the yield of and accumulation of heavy metals in rice (Oryza sativa L.). The results showed that, in the red soil, As treatment decreased rice yield significantly, except Cd treatment which showed little affect on rice yield other treatments decreased rice yields significantly, while the coexistence of Pb or Cd aggravated the toxicity of As, whereas, the combined effect of Pb-Cd-As on rice yield in other two soils was less significant than that in the red soil. But straw yields were different between the treatment Pb, Pb-Cd-As and the control (CK). In Wushan soils, only the treatment of As and Pb-Cd-As decreased rice yields compared with CK, and the combined treatments reduced straw yields. In the red soil, rice Cd concentrations of the treatments of Cd-As, Pb-Cd and Pb-Cd-As decreased by 15.7%, 11.5% and 25.6% compared with single Cd treatment, respectively. Pb treatment increased significantly rice Pb concentration in red soil, but Pb-As treatment decreased it. The concentrations of heavy metals in rice were in the following order as red soil > Qingzi soil > Wushan soil.