Based on the regional difference in soil fertility, the nutrient uptake of crop, the nutrient supplying capacity of soil and the response of fertilizers, etc., this study took the 81th regiment of the 5th agricultural division in Xinjiang Bingtuan as the training and cooperative region, and established the information system of soil nutrients for cotton fields and recommendation model of fertilization. Constructed comprehensive, digital, and intellectualized WEB-based cotton fertilization recommendation and information management decision support system by using SQL+JSP+Win2000. The system had been applied successfully in 2005 and 2006 there, and in 2006 the mean yield per hm2 increased by 7.3% than that of former 3 years, and the fertilizer cost per hm2 reduced 114 yuan (RMB).