Clinoptilolite was organicly modified by ultrasonic to improve its adsorption of benzene hexachloride. The cation surfactant was hexadecyltrimethylammonium bromide (HDTMA-Br). Single factor experiments were conducted and on this basis orthogonal experiments were conducted. The optimization methods were as follows: the HDTMA-Br concentration of 55.1 mmol/L, pretreatment temperature of 400℃ in 2h, ultrasonic handling temperature of 50℃ and ultrasonic handling time of 10 min. The removal rate of benzene hexachloride in water using clinoptilolite modified under this method was 74.1%.