An analytic method with HPLC was developed to determine the residues of cyromazine and melamine in soils. Soil samples were extracted thrice with ammonia/methanol (5/95,v/v） by ultrasonic and concentrated, and then analyzed by HPLC. The calibration curves for cyromazine and melamine were linear in concentration range of 0.1 - 15.0 μg/ml (R2=1.0000 and 0.9998, respectively）. In the concentration of 0.5-5 mg/kg, the average recoveries of cyromazine and melamine were 87.2% - 101.1% and 75.3% - 101.6% with the variation coefficient of 3.3% - 8.1% and 1.6% - 9.9% respectively. The limit of detection was 0.05 mg/kg and 0.07 mg/kg, respectively.