3 typical tobacco soils with different textures in south Anhui were selected to investigate the differences in the contents of aroma components and regular compounds in flue-cured tobacco leaves and the differences in the sensory evaluation on aroma quality. The results showed that tobacco leaves from alluvial sandy soil had high levels of carotenoid catabolites and sugar catabolites in all stalk positions, and high levels of solanone in middle leaves and high levels of phenylalanine catabolites in low leaves. Both sugar and nicotine contents were high and the ratio of sugar to nicotine was suitable. The sensory quality was good with rich sweet aroma. For clayey paddy soil, the contents of carotenoid catabolites were low in low and middle leaves, solanone was also low in middle leaves, while phenylalanine and carotenoid catabolites were high in up leaves. The content of sugar was low, while the contents of nicotine and total nitrogen were high in up leaves, which led to lower sugar nicotine ratio. The sweet aroma was not significant and the smoke was strong for up leaves. For silty sand soil, the neutral aroma components were generally at low level for middle and up leaves. The sugar content was high, while the nicotine content was low, and the ratio of sugar to nicotine was high. Sensory evaluation showed the samples had week sweet aroma and lack of aroma.