Field experiment was carried out in Yanbian to study the effects of different combinations of fertilization and irrigation on chemical components and aroma compounds of a tobacco (Nicotiana tabacum L.) cultivar Jiyan 9. The results showed that N:P2O5:K2O = 1:2:3 and limited irrigation could result in suitable ratios of total sugar/nicotine and of nitrogen/nicotine, lower protein content and higher aroma components contents of phenylalanines, browning reaction and carotenoids products, thus improved the comprehensive quality of tobacco in small odor and moderate irritation, comfortable lingering, mild smoke and good combustibility, which could satisfy the better growth of regional tobacco.