Effects of Fenton reagent made of 1mol/L H2O2 and 0.5mol/L FeSO4 on chemical remediation of PCB-contaminated soils were studied under indoor culture condition. The results showed that the removal rate of soil PCBs reached to 71.9% after the soil being treated with 20ml FeSO4 and 40ml H2O2 for 168 hours, but later, this removal effect changed a little with the increase of Fenton reagent dose and reaction time. The removal rate of Tri-Cl to Hexa-Cl PCBs in soil were 92.5%, 75.8%, 51.4% and 39.5% respectively. After adding Fenton reagent, soil pH decreased obviously while soil organic matter content changed little. The results indicated that Fenton reagent can remove effectively PCBs in soil, it is an available material for chemical remediation.