This paper firstly overviewed positive effects, reasons and mechanisms of peanut succession monocropping obstacles, secondly introduced the corresponding countermeasures for overcoming the problem with the focuses on the determination of allelopathic substance such as phenolic acids, the ecological relief technologies such as intercropping with Chinese medicinal plants, the biological and biochemical relief technologies such as adding endophytic fungus B3 ( Phomopsis sp.) based on our recent results in the red soil regions, and finally explored the general directions for the future researches in this field.