Based on the sift research and changing data of land use from 1996 to 2008, the current situation and changes of land-use spatial structure in Tianshui were analyzed by applying GIS technology and quantitative geographic model. The results indicated that there were obvious internal differences in land-use spatial structure. Firstly, the diversity index of spatial structure was comparatively high; Secondly, the garden plots and traffic lands increased obviously, though the index of land use degree fluctuated little since 1996, decreasing slightly as a whole; Thirdly, the information entropy of land use increased generally, and the total land use tended to random, the disorder degree of lands begins to increase and the types of land use are in a period of adjustment.