The field experiment by planting Lycium barbarum L. in secondary stalinization soil improved by desulfurization gypsum and special soil amendment in irrigation region of Yellow River of Hongsipu, Ningxia. We analyzed the effect of improvement that indicated that desulfurization gypsum improved slightly physical and chemical properties of soils. Desulfurization gypsum and special soil amendment decreased sand content but increased silt and clay contents, and the soil bulk density increased by 5.34%, soil porosity decreased by 5.61%, average; both soil pH and total salt content were decreased by different degrees; organic matter, nutrients and crop yield increased significantly, and the effect of amendmentⅡwas best. However, the net economical benefit of desulfurization gypsum and special soil amendment II were highest when the cost of soil amendments were considered. The improvement effect of amendment applied in autumn was better than in spring obviously; the improvement effect of physical and chemical properties of soils were better when the rate was higher, and the yield and direct economical benefit were higher. However, the net economical benefit was the highest of 11.25 t/hm2 treatment.