This paper, along the historical track and trend of DDT from its synthesis in 1874 to its elimination by 2020, partitioned first the development of DDT into 4 phases by combining the historic important events with the number of SCI-cited publications, highlighted 3 debates arose from this omnipotent pesticide: the effect of DDT on human health, use DDT or not, and how to assess DDT. Furthermore, this paper obtained some revelations from the analyses on the course of DDT from human “pet” to human “foundling”, and pointed out the warning significance to modern society.