Based on GPS technology, 144 tobacco soil samples were collected in Malong County. Descriptive analysis characteristics and spatial variation characteristics were studied. Soil feasibility index were evaluated based on geo-statistics and fuzzy mathematical theory. The results indicated that pH, organic content, available S and water-soluble Cl were suitable, total N and available N were too high, available P, available K, available Ca, available Mg, available Cu, available Fe, available Mo and available Mn were abundant, available Zn was middle, total P, total K and available B were insufficient; Anisotropic structure of nutrient indices varied evidently, spatial variability of available Ca, pH, available B and available K were mainly caused by random factors while other nutrient indices’ spatial variability caused by structural factors and random factors; Spatial distribution map of SFI showed that the areas of good, general and moderate grades were 19.63%, 59.17% and 21.01% respectively.