Taken the perennial vegetable farm in fluvo-quic soil of Haian county as the study region, the “3414’ field experiment was adopted to study the effects of fertilization on the yield, benefit, commoditization and disease resistance and the strategies for reasonable fertilization and the optimal fertilization were put forward. The result showed that the yield and benefit of combined application of NPK fertilizers were the highest, and the commodity rate was increased by 24.5%. The application of calcium fertilizer reduced the incidence of burning heart diseases by 13.2 percentage point and increased the commodity rate by 7.6%. Target yield of 120 000-150 000 kg/hm2 could be reached under N 225-255 kg/hm2, P2O5 90-105 kg/hm2, K2O 180-225 kg/hm2 with the ratio of 1 : 0.3-0.5 : 0.7-1.