Acid soil infertility is a major factor that limits crop production in red soil regions of southern China. The effects of 9-year pig manure application on amelioration of acidity on red soil (Udic Ferralsols) was studied in field lysimeter experiment with maize monoculture under different application rates of manure, i.e. N 0, 150 and 600 kg/hm2 for CK, LM and HM treatment, respectively, and with lime addition 3 t/hm2 lime every 3 years based on N 600 kg/hm2 for HML treatment. The results showed that soil pH increased year by year with increment of 0.085 in HML while manure application did not influence pH in LM. The application of pig manure increased the contents of soil base cations, especially Ca2+, followed by Mg2+. With the increase of manure application rates, the exchangeable acidity of red soil, particularly exchangeable aluminum, was obviously reduced and aluminum toxicity was eliminated after 4-year manure application. Ulteriorly, lime addition increased soil pH and reduced exchangeable acidity in comparison with HM. The manure application increased significantly corn yield on red soil. The minimal amount of manure was Ca 162 kg/hm2, over which pig manure application would increase soil pH. Lime addition once in the early years under long-term manure application would eliminate acid soil infertility with the least investments in the shortest time due to the increase and stabilization of manure on soil pH.