A simulation experiment was conducted to investigate the effect of soil pH regulation on removal of polycyclic aromatic hydrocarbons (PAHs) by slurry reaction. The results showed that slurry reaction was effective in PAHs removal from contaminated soil. About 10.6% to 20.7% of total PAHs were removed from the long-term contaminated soil, and about 37.4% to 42.1% were removed from the simulated contaminated soil. The effects differed from different PAHs. In brief, acidic condition was beneficial for 5-ring and 6-ring PAHs removal, and neutral condition was beneficial for 3-ring and 4-ring PAHs removal. Proper soil pH regulation based on the soil PAHs component would be beneficial for the remediation of contaminated soil in practice.