A pot experiment was carried out to investigate the effects of three organic amendments (organic carbon material, rapeseed cake and pig manure) on the growth and heavy metal uptake of different rice cultivars, Shanyou 63(SY63) and Zhongzheyou 1(ZZY1) in a heavy metal mixed contaminated paddy soil. The results showed that ZZY1 was a metal tolerant cultivar, the heavy metal concentration in brown rice, husk and straw were lower than that of in SY63 cultivar. Compared with SY63, the concentrations of Cd, Cu and Zn in ZZY1 brown rice decreased by 57.5% - 83.8%, 37.8% - 69.1% and 0.88% - 31.7%, respectively, and resulted in lower food-chain heavy metal risk. Application of rapeseed cake significantly decreased heavy metal concentration in brown rice of both cultivars. Compared with the control, application of rapeseed cake decreased concentrations of Cd, Cu and Zn in brown rice of SY63 by 73.5%, 52.6%, 32.1%, and Cd in ZZY1 by 30.5% respectively. This indicated that growing ZZY1 and applying proper amount of rapeseed cake to heavy metal contaminated paddy soil could decrease heavy metal concentrations in rice plant and achieve high yield with low food-chain heavy metal risk.