Growth chamber hydroponics culture and glass house pot experiment with Zn and Cd polluted agricultural soil were used to study the interaction effects of different Zn and Cd concentrations on Sedum plumbizicola growth, Zn and Cd uptake and distribution in plant. Hydroponics culture results showed that Zn and Cd concentrations in all part of plant increased significantly with Zn and Cd concentration in hydroponics solution, but there were no significant differences between the two high concentration treatments; the uneven Zn distribution was found in the plant and had relationship with Zn and Cd concentration in the hydroponic solution, for the concentration of Zn > Cd in the solution, Zn concentrations in plant were as following: the young leaves > mature leaves> the other parts >> roots, on the contrary, the order showed as: mature leaves > other parts > young leaves >> roots; Cd distribution in the plant different parts had no consistent regularity; the interaction of Cd and Zn is mainly reflected on the young leaves: when the solution was presented with Cd, low Zn concentration in solution had synergy effects on Cd concentration in young leaves, and high Zn had antagonistic effect; Cd also had antagonistic effect on Zn concentration in young leaves. The soil pot experiment results also showed that the high Zn could promote plant Cd uptake, and Cd had antagonistic effect on the uptake of Zn. Extremely high Zn or Cd would significantly inhibit plant growth, and thus lower remediation efficiency.