This paper investigated the removal of polychlorinated biphenyls (PCBs) in the simulated and site contaminated soils with the combined method of elution with hydroxypropyl-β-cyclodextrin (HPCD) and polyoxyethylene lauryl ethe (Brij35) and sodium persulfate (SPS) oxidation. The effects of elution time, soil/liquid ratio and eluent concentration on the elution efficiency of PCBs from the soil as well as the effect of SPS concentration on the degradation of PCBs in elution were examined. Results indicated that 90% and 79% of PCB28 was eluted from simulate contaminated soil with soil/liquid ratio of 1︰20, elution time of 4 h, and 20 g/L of HPCD and 8.0 g/L of Brij35, respectively. After that, the elution was oxidized by persulfate for 24 h and 90% and 92% of PCB28 were degraded by 100 g/L SPS in HPCD and Brij35 elutions, respectively. Furthermore, HPCD or Brij35 elution combined with persulfate oxidation processes was also applied for the removal of PCBs in site contaminated soils, which contained approximately 1400 mg/kg of PCBs. The results indicated that 66% and 53% of PCBs were removed from the soils with the optimum conditions. Similarly, persulfate also exhibited excellent ability to degrade PCBs in HPCD and Brij35 elutions, and about 41% and 52% of 10.6 mg/L PCBs were degraded in the presence of 100 g/L persulfate within 24 h. This study developed an efficiently method for the removal of PCBs from soils, and provided a new strategy for the remediation of PCBs contaminated soils.