Tiered human health risk assessment of soil and groundwater were undertaken for a typical organic chemical contaminated site in southern China. The screening levels and remediation targets of chemicals of concern (COCs) in soil and groundwater, as well as the corresponding remediation area were calculated. The results indicated that both soil and groundwater were contaminated by organic compounds with different levels. The derived remediation targets of chloroform, carbon tetrachloride, benzene, chlorobenzene were 0.03, 0.05, 0.35, 6.51 mg/kg in the 0 – 1 m soil layer; 0.07, 0.30, 0.90, 13.49 mg/kg in the 1 – 3 m soil layer; 0.14, 0.46, 1.69, 20.45 mg/kg in the 3 – 5 m soil layer; 0.25, 0.79, 2.99, 36.27 mg/kg in the 5 – 9 m soil layer, and 0.32, 0.51, 3.43, 21.80 mg/L in the groundwater, respectively. The soil contaminated points of chloroform, carbon tetrachloride and chlorobenzene, as well as their corresponding cancer risk or hazard index values were increased with the increase of soil depth. The contaminated area of groundwater were gathered together. The concentrations of four COCs in groundwater (GW6) were beyond their remediation targets, and chloroform was the most serious contaminant with cancer risk and hazard index of 1.11×10–3 and 9.8, respectively.