Urbanization in China developes fast in recent decades. Land use/cover change (LUCC) is the key reason causing the evolution of Quanzhou City’s eco-environment. Therefore, quantitative analysis for the spatiotemporal patterns of Quanzhou’s urbanization can provide not only theoretical basis for future regional environment assessment, but also scientific basis for the construction of Western Taiwan Straits Economic Zone and geopolitical strategy “One Belt One Road”. However, due to the complexity of urban LUCC and the restriction of multi-disciplinary integration, the inter-regional land use quantitative analysis based on remote sensing imagery interpretation is relatively immature. This study adopts Geographic Information System (GIS) and the remote sensing method, with the land-use data of 1995, 2000, 2005 and 2010 recorded from remote sensing images as main data sources, to comparatively study the land-use quantitative characteristics, dynamic and change process of Quanzhou City in Fujian Province, China with the views of cross region in the latest 15 years. The results showed that in 2010, as the main land use types in Quanzhou City, forest land and cropland accounted for 60% and 15% of the total area respectively. Our data show that constrction land in Quanzhou City increased more than twofold from 1995 to 2010, the areas of cropland and forest land decreased distinctly and about 57.4% of the converted cropland became into constrction land. Most urban land expansion concentrated in the coastal areas, including the city districts and areas with the dominance of labor intensive industries. The comprehensive dynamic degrees of each period were 7.87, 5.18 and 3.85 in a descending order; correspondingly, the land use degree showed a decreasing tendency of being tense at first but loose afterwards in the different periods. According to contemporaneous trans-regional comparative analysis, the comprehensive land use dynamic degree of is 5.8 for Quanzhou City, 5.5 for Changzhutan region of Central China, 11.3 for Xiamen, and 1.79 for Liupan Mountain Region of southern Ningxia, which reveals a decreasing tendency from Eastern and Middle China to Western China, and this is related to the economic development, periodicity and regionality of land use. Although urban land expansion in Quanzhou City is remarkable since 1995, it falls behind Shenzhen and Dongguan in the Pearl River Delta, the most populated and developed regions in China. Geographic location and population growth are the main driving factors. From 1995 to 2010, Quanzhou’s landscape became increasingly more diverse in land use, more fragmented in the structure and more complex in shape. Number and structure of population, economic development and the national policies of developing Western Taiwan Straits Economic Zone are the main driving forces that influence the regional land use. Therefore, the major taskes ahead will be the better control of urban expansion in the eastern and central region, and better coordination of allocating land to different uses.