Heavy metal pollution of soil in some regions has been causing increasingly serious problems due to the overdevelopments of natural resources by human beings. In-situ immobilization technology by addition of various stabilizers to soil has been proven to be one of the most effective ways in soil remediation. The heavy metal contaminants can be retained in stable solid phase through the effects of adsorption, precipitation or co-precipitation, ion exchange, and chemical coordination, thereby the mobility and bioavailability of the heavy metals were decreased. This review summarized various stabilizers reported in recent years and their application in remediation of heavy metal-contaminated soil. The mechanisms for the stabilization of heavy metals in soil were also discussed. The development trends were forecasted on the basis of the structure-activity relationship of the stabilizers.