A field plot experiment was conducted in order to study the effects of five kinds of soil amendments made from different agricultural and forest residues on soil properties under tobacco-rice rotation and on flue-cured tobacco yield and quality. The results showed that: all the soil amendments improved the physical characteristics of tobacco-planting soil by decreasing soil bulk density and increasing soil field capacity. Soil amendments obviously improved the growth of tobacco plants: In rosette stage, leaf width of amendment X1 was significantly larger than CK; In fast-growing stage, leaf lengths of amendment X1, X2 and X5 were significantly larger than CK, leaf area of amendment X5 was significantly greater than CK; In mature stage, upper and lower leaf lengths of amendment X1, X2 and X5 were significantly higher than CK. Root weight had a significant correlation with flue-cured tobacco yield (r=0.907, P<0.05). Amendments, particularly X3 and X5 increased significantly tobacco yield compared to CK. Amendments increased the proportions of first-class and middle-class flue-cured tobacco compared to CK. Amendments improved the quality of tobacco leaf appearance, amendment X1, X2 and X3 significantly increased the total score of first-class flue-cured tobacco compared to CK. The above results provide the application prospect of the above soil amendments in south Anhui tobacco-planting soil.