In order to provide scientific references for tobacco planting, reasonable fertilization and improvement of tobacco quality, the spatial distribution characteristics of available nutrients of tobacco planting soil in Yanyuan, Sichuan Province were investigated using geostatistics and the effects of the influencing factors on these characteristics were examined by regression analysis. The results indicated: 1) The means of soil available N (AN), available P (AP) and available K (AK) in the study area are 102.84, 10.18 and 148.10 mg/kg, respectively, and all of them are in the middle level. Their coefficients of variation are 38.66%, 90.08% and 60.65%, respectively, and reached middle variation degree, showing uneven spatial distribution. 2) The exponential model fitted spatial distributions of soil AN and AP well with a moderate spatial dependence, while Gaussian model fitted soil AK well with a high spatial dependence. The spatial variabilities of the nutrients are affected by structural and random factors synchronously. 3) The spatial variabilities of tobacco planting soil AN, AP and AK in Yanyuan have different main controlling factors. The main controlling factors of AN are slope and previous crop. The factors for AP are soil type and previous crop and are altitude and slope for soil AK. Therefore, various influencing factors need to be considered for selection of tobacco planting soils and fertilization.