To provide a theoretical basis for tobacco-planting soil improvement, balanced fertilization and developing high-quality tobacco in Karst area, this study analyzed the spatial heterogeneity and correlation characteristics of surface soil pH, available Fe, available Mn and exchangeable Ca of tobacco-planting area in Youyang County of Chongqing by the combined methods of field surveys, classical statistical and geostatistical methods. The results showed that soil pH was generally acidic and available Fe, available Mn and exchangeable Ca were rich in the tobacco-planting area. pH, available Fe, available Mn and exchangeable Ca belonged to middle variation and were relatively stable in soil with variation coefficient between 5.690%– 7.338%. The nugget effects of them were between 5.690%–7.338%, with strong spatial correlation. In the spatial distribution, pH and exchangeable Ca were high in the west and low in the east, available Fe was high in the east and low in the west, richest from the central to the southwest. Available Mn generally was low in the middle, but high around the periphery. pH had significant negative correlations with available iron and Mn, had significant positive correlation with exchangeable Ca. Overall, the nutrient elements belonged to middle spatial variability and had strong spatial correlation in the study area.