In this study, a field experiment was carried out in the rice-wheat rotation area of Chengdu Plain from 2012 to 2014 to study the dynamic changes of enzyme activities rhizosphere and non rhizosphere soils during the wheat-growth season in order to provide a scientific basis for the reasonable application of agricultural wastes. Five treatments were designed including CK, chemical fertilizer, straw returning + pure chemical fertilizer, straw returning + low amount of pig manure to replace chemical fertilizer, straw returning + high amount of pig manure instead of chemical fertilizers. The results showed that the activities of soil catalase and invertase were significantly higher in rhizosphere than that in non-rhizosphere (P<0.05) under the same treatment; pig manure with straw treatments improved soil catalase activity, returning straw and pig manure treatments improved soil invertase activity; during the whole growth period of wheat, the activities of soil catalase in rhizosphere and non-rhizosphere showed a decreasing trend; however, soil invertase activity fluctuated largely in rhizosphere and showed single peak in non-rhizosphere.