A pot experiment was conducted to study the effects of intercropping with post-grafting generation of Solanum photeinocarpum on photosynthetic physiology of loquat seedlings under cadmium (Cd) stress, in which 4 post-grafting generations of S. photeinocarpum were intercropped with two kinds of loquat seedlings (Dawuxing and Chuanzao) in Cd-contaminated soil. The results showed that, compared with the monoculture, intercropping significantly improved chlorophyll a, chlorophyll b and total chlorophyll contents, net photosynthetic rate, transpiration rate, intercellular CO₂ concentration, stomatal conductance and soluble sugar content of loquat seedling, decreased the vapor pressure deficit on leaf surface. SPAD and net photosynthetic rate, transpiration rate, intercellular CO₂ concentration, stomatal conductance of the post-grafting generation of S. photeinocarpum inter crop-Red were higher than those of monoculture, while the soluble sugar content was lower, the vapor pressure deficit on leaf surface of the post-grafting generation of S. photeinocarpum intercropped with Dawuxing seedling was higher than the that of monoculture, but the early Sichuan loquat was lower. Therefore, the post-grafting generations of S. photeinocarpum intercropping with loquat could enhance the photosynthesis of these two plant species, thus could promote the growth of them.