To investigate the physiological and biochemical characteristics of wheat seedlings under salinity and drought, an indoor pot experiment was conducted from March to May in 2017. Two NaCl concentrations of S1 and S2, two water contents of W1 and W2 were designed. The dry weights and the contents of total nitrogen, chlorophyll and soluble sugar of shoots and roots were measured for potted winter wheat. The results showed that: ① The increase of salinity significantly limited the growth of wheat. The dry weights of shoots and roots, total nitrogen and chlorophyll contents of winter wheat decreased significantly but the soluble sugar content increased. ② Interaction of low salt with drought alleviated the restriction on the growth of wheat seedlings, the dry weights of shoots and roots and the contents of nitrogen, chlorophyll and soluble sugar of winter wheat were highest. ③ Interaction of high salinity with drought aggravated the restriction on the growth of wheat seedlings. The above results suggest that low salinity with moderate drought stress could stimulate stress effects of wheat, which is beneficial for the growth of wheat seedling.