To analyze the status and changes of soil nutrients, 81 and 96 tobacco-growing topsoil samples in Fuing county were collected in 2012 and 2017, respectively. Soil feasibility index (SFI) and nutrients variation characteristics were evaluated and analyzed based on fuzzy mathematical theory, t-test and multiple comparison. Results showed that soil pH was ranged from 4.41 to 8.12; SOM ranged from 7.62 to 39.99 g/kg, and the middle suitability proportion was 71.88% of the total samples; soil total N and mainly available nutrients were over high. In 2017, the average of SFI of tobacco-growing soil was 0.6, the coefficient of variation was 26.17%, and the fertility was evenly distributed and the spatial variation was small, the proportion of SFI above the II grade was 46.88%. Compared to 2012, soil pH was increased by 0.54, the contents of organic matter, total N, available N, available P and available K increased by 1.69 g/kg, 0.58 g/kg, 24.63 mg/kg, 17.2 mg/kg and 66.6 mg/kg in 2017, respectively. These results suggest that soil acidification has been alleviated, the contents of nitrogen, phosphorus, potassium and organic matter have gradually increased. Therefore, soil improvement need to be continued, meanwhile nitrogen application should be strictly controlled and the effectiveness of phosphate fertilizer should be enhanced in tobacco production.