With the cherry tomato "Millennium" as the test material, the effects of ratio of Se-enriched & high calcium organic fertilizer and compound fertilizer (50 kg compound fertilizer per 667 m², 500 kg Se-enriched & high calcium organic fertilizer + 25 kg compound fertilizer per 667 m², 1 000 kg Se-enriched & high calcium organic fertilizer per 667 m²) and irrigation amount (100% irrigation amount, 80% irrigation amount) on tomato yield and quality under drip irrigation were studied. The results were as follows: 1) the yield of combination Se-enriched & high calcium organic fertilizer with compound fertilizer was significantly higher than that of Se-enriched & high calcium organic fertilizer or compound fertilizer with the same amount of NPK; 2) the contents of selenium, lycopene, vitamin C and soluble sugar in tomato fruit were significantly increased with the increase of the fertilizer amount of Se-enriched & high calcium organic fertilizer; 3) drip irrigation effectively improved the utilization efficiency of water, and selenium content and tomato quality were improved under the condition 80% irrigation while the yield was not significantly reduced. Therefore, treatment of combination Se-enriched & high calcium organic fertilizer with compound fertilizer (equal weighting) and 80% irrigation with drip irrigation is more feasible, as tomato quality is significantly improved and tomato yield is guaranteed.