In order to find the optimal irrigation pattern and reasonably and effectively utilize the water resources of Hetao Irrigation Area, joint irrigation patterns with two kinds of water sources, well water (groun dwater) and canal water (surface water) was adopted to study their effects and mechanism on the growth of corn and water and salt accumulation in soil. Nine different irrigation patterns were designed, which included: well-well-well(JJJ), well-well-canal(JJQ), well-canal-well(JQJ), canal-well- well(QJJ), well-canal-canal(JQQ), canal-canal-well(QQJ), canal-well-canal(QJQ), canal-canal-canal(QQQ), and CK (no irrigation and fertilization). The results showed that with increase of well irrigation time, the inhibition became more obvious to the plant height and stem diameter of corn, and the inhibition degree was in an order of the jointing stage > filling stage > heading stage. Salt accumulation happened under all treatments but with different degrees during the growth period of corn. Salt was accumulated more in the tilling layer than in the deep layer. Soil salt accumulation became more evident with the increase of well irrigation times. The change of soil salt content in the tillage layer was lower under QJQ treatment than under other well irrigation treatments, and was near to QQQ treatment. Canal irrigation at the jointing stage could effectively wash soil salt. Well irrigated twice or more decreased water use efficiency by 25.77%-31.61% than those of well irrigated one time and irrigation without well water. Water use efficiency of QJQ treatment was higher than those of other treatments with well irrigation. QQQ treatment had the highest harvest index and nitrogen fertilizer partial productivity, followed by QJQ treatment, while JJJ treatment was the lowest, and no significant difference was found in harvest index and nitrogen fertilizer partial productivity between QQQ and QJQ treatments. Comprehensive analysis the dynamics of water and salt in soil and crop index and so on, QJQ treatment is recommended as the optimal multi-water irrigation scheme for local maize in the study area.