A field experiment was conducted to determine the optimum fertilization scheme for reclaimed homestead in Chengdu Plain. Eight treatments were set up which included blank control (CK, no material input), conventional fertilization (CF, N 150 kg/hm² and 180 kg/hm², P₂O₅ 75 kg/hm² and 100 kg/hm², K₂O 75 kg/hm² and 120 kg/hm² in wheat and maize seasons, respectively), conventional volume straw returning (T1), high volume straw returning (T2, 1.5×T1), conventional volume mushroom residue returning (T3), high volume mushroom residue returning (T4, 1.5×T3), conventional volume pig manure returning (T5), and high volume pig manure returning (T6, 1.5×T5). Topsoil samples (0-20 cm) were collected and 10 indexes were measured which included soil bulk density, porosity, pH, total organic carbon, total nitrogen, total phosphorus, total potassium, alkali-hydrolyzed nitrogen, available phosphorus and available potassium, and then soil comprehensive fertility were evaluated. The results showed that the combined application of straw, mushroom residue and pig manure with chemical fertilizer improved the physical properties of the reclaimed soil and increased significantly the contents of total organic carbon, total phosphorus, alkali-hydrolyzed nitrogen, available phosphorus and available potassium (P<0.05). T6 treatment had the best effects in promoting total organic carbon and total nutrients, while T4 treatment had the best effects in promoting available nutrients and soil comprehensive fertility with an average annual increase of 0.385 grade. Thus, it is recommended that high volume mushroom residue returning treatment (T4) as the optimum fertilization for reclaimed homestead in Chengdu Plain, i.e, applying 8 507 kg/hm² and 9 411 kg/hm² of mushroom residue, 307 kg/hm² and 324 kg/hm² of urea, 825 kg/hm² and 925 kg/hm² of calcium superphosphate, 38 kg/hm² and 172 kg/hm² of potassium chloride in wheat and maize seasons, respectively.