A four-year field experiment was conducted in Fangcheng County of Henan Province to disclose the relation between crop yield and soil properties at jointing and maturity stages of winter wheat planted with biochar application (+B) or not (-B), and both contained three treatments of chemical fertilizers (NPK), chemical fertilizers plus straw (NPK+S), and an amended control (CK). The results showed that biochar and straw had no interaction effect on wheat yield. The average wheat yield was reduced by 17.4% following continuous application of biochar for 4 a. Compared to CK, wheat yield of NPK+S and NPK treatments increased by 33.8% and 37.4%, respectively, while no significant differences in wheat yield existed between NPK+S and NPK treatments. Relationships between wheat yield and soil properties at jointing or maturity stages were obtained using PLS-PM model, and it was found that wheat yield was affected mostly by N supply at jointing stage, while soil properties had less effect on wheat yield at maturity stage. In conclusion, more attentions should be paid to N supply at jointing stage of wheat in the yellow-cinnamon soil to prevent yield decrease after biochar and straw are applied.