In this study, sample pairs of 116 topsoil and Chrysanthemum morifolium were collected from the representative areas in Bozhou City of Anhui Province, 11 soil fertility indicators were measured, the growth and yield indexes of C. morifolium were obtained, 8 soil fertility indexes were identified, including organic matter, EC, available N, P, Ca, S, Fe and Cu, and a minimum data set (MDS) was established through the principal component analysis, then soil integrated fertility index (IFI) was calculated based on the correlation coefficients of MDS indexes and C. morifolium growth and yield indexes, and the relationship between soil fertility indexes and C. morifolium growth and yield indexes were further explored. Results showed that soils in C. morifolium planting area in Bozhou generally were weakly alkaline with low salinity and organic matter, high nutrients retention ability, sufficient in macro and medium nutrients but insufficient in micronutrients. Soil IFI generally was moderate (70.69% of soil samples with in the moderate IFI grade), with low micronutrients contents being the main limiting factors. Generally, C. morifolium prefers the neutral soil with sufficient nutrients supply, soils with higher IFI are more conducive to the growth and yield increase of C. morifolium, but excessive sulfur input due to fertilization may retard to the growth and yield of C. morifolium.