Heavy metal-polluted farmland directly affects food security and sustainable development of agriculture. Safe utilization technology can decrease the uptake and accumulation of heavy metals into crops and thereby cut down the risk of heavy metals into the food chain through primarily reducing the bioavailability of heavy metals in soils, which is of great significance for the effective application of heavy metal-polluted farmland resources and the protection of crop safety at current stage in China. Therefore, this paper firstly analyzed the pollution cause and current situation of heavy metals in farmland soil, then reviewed the research progress of different safe utilization technologies including low accumulation crop variety screening, water and fertilizer management, intercropping or crop rotation, in situ passivation and foliar resistance control, and finally proposed the strategies of strengthening the research and practice of safe utilization in heavy metal-polluted farmland.