The effects of different concentrations of Sapindus (WHZ) and EDTA-2Na on the removal of Pb and Cd were investigated by oscillatory leaching test, the suitable leaching method was selected, the best leaching parameters were explored, and the morphological changes of Pb and Cd before and after leaching were analyzed. The results showed that the solid-liquid ratio of “WHZ+EDTA-2Na” leaching parameters was 1:3, the optimal dosage was 1 g EDTA-2Na, the concentration of Sapindus crude extract was 5 g/L, and the removal rates of Cd and Pb reached 76.50% and 73.40%, respectively, after 2 h of leaching. The effect of Sapindus crude extract combined with low concentration EDTA-2Na was better than that of single leaching, and the combination of the two was the best. Form analysis showed that the complex eluent had a good elution effect on the exchangeable state of Cd and Fe-Mn oxide state of Pb in soil.