This field experiment examined the growth, yield, Cd reduction, as well as the transfer mation and accumulation of Cd in six wheat varieties through foliar sprayings of nano-ZnO, nano-MnO₂, and their mixtures. The results indicated there were significant differences in the yields, the contents and uptakes of Zn and Mn of the six wheat varieties. Foliar applications of these three nanomaterials had no significant impacts on the plant heights across different wheat varieties. However, it significantly increased the theoretical yields of Zhoumai 36 and Jiangmai 919. Moreover, Cd concentrations in the grains of Xinong 619, Zhoumai 36, Huawei 305, Shengmai 21, Jiangmai 919 and Yannong 919 were reduced by 11%-35%, 10%-46%, 10%-38%, 28%-40%, 37%-53%, and 15%-27%, respectively. Additionally, foliar spraying of nano-ZnO significantly increased Zn contents by 4%-20% in the grains of Xinong 619, Zhoumai 36, Huawei 305, Jiangmai 919 and Yannong 919. Similarly, foliar spraying of nano-MnO₂significantly increased Mn contents by 2%-9% in grains of Zhoumai 36, Huawei 305, Jiangmai 919 and Yannong 919. In conclusion, different wheat varieties have different transfer mation and accumulation patterns of Cd, Zn and Mn, and different materials should be selected for leaf spraying according to the wheat varieties.