In order to explore the effect of in situ immobilization remediation combined with foliar spraying of ZnO on the transport and accumulation of cadmium (Cd) in different wheat cultivars in a weakly alkaline soil. In this study, the effects of applying iron tailings and lime into soil, foliar spraying of ZnO, and the combination of the two on the accumulation of Cd in the kernels of three wheat varieties were evaluated through a field experiment, and the changes of different forms of Cd in the soil as well as its transport and enrichment patterns among different parts of the wheat were analyzed. It was found that in situ immobilization combined with foliar spraying of ZnO effectively reduced the bioavailability of soil Cd, which in turn reduced Cd content in wheat kernels, especially in wheat varieties with high capacity for Cd accumulation. Compared to the control, the treatments reduced Cd content in wheat grains by 20.81%-31.67%, 2.48%-11.39% and 5.75%-10.92%, respectively. In addition, in situ immobilization and its combined application with foliar spraying of ZnO reduced the availability of Cd in soil by 7.19%-11.25% and increased soil pH by 0.4-0.9 units. The results also showed that the combined treatment reduced the upward translocation and accumulation of Cd in the soil-wheat system and had a variety-dependent effect on Cd translocation and accumulation in different wheat varieties. This study provides a strategy to reduce the accumulation of Cd in wheat through agronomic management practices.