To investigate the main soil fertility indicators in the tobacco-growing areas of Yibin City, Sichuan Province, and provide a theoretical basis for scientific fertilization, in this study, 94 soil samples (0–20 cm) were collected from four major tobacco-growing areas in Yibin, soil fertility indicator including pH, organic matter (OM), total nitrogen (TN), alkali-hydrolyzable nitrogen (AN), total phosphorus (TP), available phosphorus (AP), total potassium (TK), available potassium (AK), and available sulfur (AS) were determined and analyzed using descriptive statistics, principal component analysis, and fuzzy comprehensive evaluation methods. The results showed that average pH was 6.29, with 86.17% of the fields within the most suitable range. OM was generally rich, with 10.64% of the fields at the deficient level. TN was excessively high in 56.38% of the fields. AN was appropriate in 35.11% of the fields. TP was suitable in 31.91% of the fields, but deficient in 10.64%. AP was suitable in 78.72% of the fields. TK was excessively high in 54.26% of the fields. AK content was very rich, with 68.09% of the fields at the excessively high level. AS content was also very rich, with 94.68% of the fields at the excessively high level as well. There were differences in soil integrated fertility index (IFI) among the four main tobacco-growing counties, ranking as follows: Xingwen County (0.62, Grade Ⅱ) > Junlian and Gong counties (0.59, Grade Ⅲ) > Pingshan County (0.56, Grade Ⅲ). The rational fertilization strategy should include "N precision control, P reasonable adjustment, categorized applying organic fertilizers, and strict control of S-containing fertilizer based on different soil characteristics and crop requirements."