In order to solve the problem of increasing obstacle of continuous cropping of flue-cured tobacco in tobacco-growing area of Weifang, Shandong Province in recent years, a field experiment was conducted with three field treatments: continuous cropping (CK), tobacco-ryegrass (Dongmu 70) rotation (T1), and tobacco-oilseed rape rotation (T2). Differences in yields, economic values, and forage qualities of the two crops were analyzed, the effects of different crop rotations on soil fertility, as well as the growth, yield and quality of tobacco leaves were investigated. The results showed that the yield, economic value and nutritional quality of ryegrass were significantly higher than those of oilseed rape, planting ryegrass and oilseed rape increased the income by 1.70×10⁴ yuan/hm² and 1.51×10⁴ yuan/hm², respectively. Tobacco-ryegrass rotation was superior to tobacco-oilseed rape rotation in improving soil quality, tobacco yield and quality of tobacco leaves. Compared with CK, soil organic carbon, dissolved organic carbon and available potassium contents of tobacco-ryegrass rotation increased by 20.81%, 188.9%, and 50.68%, respectively, and chlorine content decreased by 21.36%, the leaf development of flue-cured tobacco was accelerated in the middle and late stages, and the economic benefit of tobacco leaves was increased by 5 904 yuan/hm², and the structure, oil content, and appearance quality of tobacco leaves were obviously improved, and the potassium content of tobacco leaves was increased by 14.10% while chlorine content decreased by 40.28%. Tobacco-ryegrass rotation is worth promoting in Weifang tobacco-growing area.