Wheat consumption is an important source of human cadmium (Cd) intake. The excessive Cd in wheat has aroused the public concern. Decreasing the Cd accumulation in wheat is one of the effective and practical strategies to reduce the risk of Cd exposure of Chinese residents. This study examined the growth, yield, Cd reduction, as well as the transfer and accumulation of Cd in six wheat varieties through foliar sprayings of nano-ZnO, nano-MnO2, and their mixtures. The results indicate significant differences among the six wheat varieties in terms of yield, zinc, manganese content, and uptake. Foliar applications of these three nanomaterials had no significant impacts on the plant height across different wheat varieties. However, it significantly increased the theoretical yield per acre of Zhoumai 36 and Jiangmai 919. Moreover, Xinong 619, Zhoumai 36, Huawei 305, Shengmai 21, Jiangmai 919, and Yannong 919 reduced the Cd concentration in wheat grains by 11-35%, 10-46%, 10-38%, 28-40%, 37-53%, and 15-27%, respectively. Additionally, foliar spraying of Zn significantly increased the Zn contents in wheat grains of Xinong 619, Zhoumai 36, Huawei 305, Jiangmai 919, and Yannong 919 by 4-20%. Similarly, foliar spraying of Mn fertilizer significantly increased the Mn contents in wheat grains of Zhoumai 36, Huawei 305, Jiangmai 919, and Yannong 919 by 2-9%. Overall, different wheat varieties have different transfer and accumulation patterns, and different leaf spraying materials should be selected according to the varieties.