A field experiment was conducted to explore the suitable drip fertigation modes for tobacco top-dressing, in which three modes of drip fertigation for tobacco top-dressing, including twice, three, and four times of drip fertigation for tobacco top-dressing were studied for their effects on the biomass of tobacco, soil mineral nitrogen content, and the absorption and utilization of nitrogen, phosphorus, and potassium, with the conventional dry fertilization as the control. Results showed that with the increase of drip fertigation times, the biomass of tobacco leaves and the whole plant at maturity stage, as well as the average content of soil mineral nitrogen during the vigorous growth stage and the whole growth stage, increased accordingly. Nitrogen and potassium contents in the leaves, as well as the accumulation and nitrogen use efficiency, phosphorus, and potassium, also increased with the increase of drip fertigation times. There was a significant correlation between the nitrogen accumulation in the leaves and the whole plant at maturity stage and the average content of soil mineral nitrogen during the vigorous growth stage (r=0.526～0.816, P<0.01). Compared with dry top-dressing, there was no significant difference in the utilization rates of nitrogen and potassium fertilizers in the treatments of twice and three times drip fertigation for tobacco top-dressing (P>0.05). However, the use efficiency of nitrogen and potassium fertilizers were significantly improved by 57.7%（P＜0.05）and 58.5%（P＜0.05）in the treatment of four times of drip fertigation for tobacco top-dressing, while the phosphorus fertilizer use efficiency significantly decreased by 35.7%~50.0%（P＜0.05）in all drip fertigation treatments, with no significant difference among all fertigation treatments（P＞0.05）. Compared with twice and three times of drip fertigation, four times of drip fertigation for tobacco top-dressing was beneficial for maintaining and stabilizing soil mineral nitrogen content during the vigorous growth stage, promoting the growth, development, and nutrient absorption and utilization of tobacco plants, which is considered the most suitable drip fertigation mode for tobacco top-dressing in the experimental area.