To investigate the main soil fertility indicators in the tobacco-growing areas of Yibin City, Sichuan Province, and provide a theoretical basis for scientific fertilization, this study employed descriptive statistics, principal component analysis, and fuzzy comprehensive evaluation methods. We collected 94 soil samples from four major tobacco-growing areas in Yibin and analyzed the following nutrients: pH, OM (Organic Matter), TN (Total Nitrogen), AN (Alkali-hydrolyzable Nitrogen), TP (Total Phosphorus), AP (Available Phosphorus), TK (Total Potassium), AK (Available Potassium), and AS (Available Sulfur). The results indicate that the average pH in Yibin's main tobacco-growing soils is 6.29, with 86.17% of the fields within the most suitable range. OM content is generally rich, but 10.64% of the fields are at a deficient level. TN is excessively high in 56.38% of the fields. AN is at an appropriate level in 35.11% of the fields. TP is suitable in 31.91% of the fields, but 10.64% are deficient. AP is at an appropriate level in 78.72% of the fields. TK is excessively high in 54.26% of the fields. AK content is very rich, with 68.09% of the fields at an excessively high level. AS content is also very rich, with 94.68% of the fields at an excessively high level. There are differences in the IFI (Integrated Fertility Index) among the four main tobacco-growing counties in Yibin, ranking as follows: Xingwen County (0.62, Grade II) > Junlian County and Gong County (0.59, Grade III) > Pingshan County (0.56, Grade III). The fertilization strategy should include "precision N control, reasonable P adjustment, categorized application of organic fertilizers, and strict control of S-containing fertilizer use based on different soil characteristics and crop requirements, while adjusting and controlling fertilization amounts according to local conditions."