The effects of different doses of compound biofertilizer on the content of soil available N, P, K and growth of maize and lettuce were studied by the pot experiment. The results showed that application of compound biofertilizer could obviously increase the content of soil available N, P and K. The amounts of N, P and K uptaked by maize and lettuce increased significantly by compound biofertilizer with a dose of N 0.1 g/kg soil, and the maize biomass increased significantly by compound biofertilizer with a dose of N 0.1 g/kg soil.