A method of soil sampling point arrangement based on GIS based in Tongxu County, eastern Henan Province was conducted after some basic rules such as covering the studied soil and its species, combining surface and profile soil sampling points together and integrating grid points and soil type control points. 2 km × 2 km grids were created for arranging 157 soil sampling points including 141 ordinary and 6 type control grid spots, as well as 10 type control reference points, matching all the 16 soil types of the region. The layer of samples was overlaid with the soil map to establish a database of soil sampling point attributes and spatial patterns by which 135 topsoil sites and 15 profiles were actually collected. It is a more convenient way to search and update the soil information by layer-managing the soil sampling points in the database, for instance, some changes since the 2nd general national soil survey during sampling in 1980’s have taken place so that it is needed to diagnose the soil type and improve the initial soil map.